9597. 'With cherubs' means the Lord's watchfulness, guarding it from the approach of the hells and the harm they can do. This is clear from the meaning of 'cherubs' as watchfulness and providence, preventing any approach to the Lord except through good and protecting from harm the good from the Lord which exists in heaven and with man, dealt with in 9509, consequently guarding heaven from the approach of the hells and the harm they can do.

'Upon' or 'over' signifies being spiritually higher, or interior.

(References: Apocalypse Revealed 900)