Lamentations 2:21

²¹ The child and the old man lie on the ground in the streets; my virgins and my young men are fallen by the sword: thou hast slain [them] in the day of thine anger; thou hast killed, thou hast not spared.

The living creatures not resting day or night

In Revelation 4:8, this signifies that what the Word continually teaches is that the Lord Jesus Christ alone is God, and is alone to be worshipped. (Apocalypse Explained 285, Apocalypse Revealed 247)