In Genesis 2:14 and Psalms 80:9, 10, the Euphrates symbolizes secular knowledge — facts — and the sensory impressions on which facts are based. (Secrets of Heaven 120)

380. Verse 12 When you till the ground, it will not yield its strength a wanderer and a fugitive you will be in the land.

'Tilling the ground' means cultivating this schism or heresy. 'Not yielding its strength to you' means that it is sterile. 'Being a wanderer and a fugitive in the land' means not knowing what truth and good are.