There are two ways "brother" is used in the Bible, ways that are still reflected in modern language. One denotes an actual blood relationship; the other is a more sweeping term of commonality, in such as in the phrase the "brotherhood of man." In general 'brother' in terms of the blood relationship refers to the unity that can exist between the desire to do good and the understanding of how to do good. This is true of Cain and Abel and several pairs of twins: Jacob and Esau, Judah's sons Zarah and Pharez, and Joseph's sons Ephraim and Manasseh; in each case one represents the desire for good and the other the understanding of truth.

1007. 'At the hand of man' means from his entire will, and 'at the hand of brother man' from his entire understanding. This is clear from the meaning of 'man' (homo), for the essential element and life of a person is his will - indeed the character of the will determines that of the person; and from the meaning of 'brother man' (vir), for where the understanding resides in man it is called 'brother man', as shown already in 367. Whether the understanding residing there is true, spurious, or false, it is still called 'brother man'. In fact the understanding is called 'a man' (vir), 158, 265, and 'the brother' of the will, 367. The reason why a defiled will and a defiled understanding are here called 'a man' (homo) and 'brother man' (vir) is that the subject here is profanation, the mere mention and consequent representation of which is not tolerated in heaven but instantly rejected with disgust. This is why such mild expressions are employed here. The sense of the words of the verse can be taken two different ways so to speak, so as to prevent those in heaven knowing that this verse contains such matters.