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Genesis 25:22

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22 and the children struggle together within her, and she saith, `If [it is] right -- why [am] I thus?' and she goeth to seek Jehovah.

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Genesis 26:4

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4 and I have multiplied thy seed as stars of the heavens, and I have given to thy seed all these lands; and blessed themselves in thy seed have all nations of the earth;

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Genesis 25:24-26

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24 When her days to be delivered were fulfilled, behold, there were twins in her womb.

25 The first came out red all over, like a hairy garment. They named him Esau.

26 After that, his brother came out, and his hand had hold on Esau's heel. He was named Jacob. Isaac was sixty years old when she bore them.