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22 Nevertheless I withdrew my hand, and wrought for my name's sake, that it should not be profaned in the sight of the heathen, in whose sight I brought them forth.
In Revelation 17, this signifies the Roman Catholic Church. (Apocalypse Revealed 723)
5 And I myself will fight against you with an out-stretched hand and with a strong arm, even in anger, and in fury, and in great wrath.