In Revelation 4:7, this signifies the divine truth of the Word as to knowledges and the understanding therefrom. (Apocalypse Revealed 244)

They signify also the divine intelligence in the Lord's protection and providence. (Apocalypse Explained 281)

Down" is used many different ways, and its spiritual meaning in the Bible is highly dependent on context. Phrases like "bowing down," "lying down" and "falling down" are defined primarily by "bowing," "lying" and "falling"; there is also a great difference between a person descending, the Lord sending fire from heaven and someone handling an object, to offer a few examples. In a very general sense, though, "down" indicates a lowering from more internal spiritual states to more external ones. That's why the journey is described as going "down" to Egypt from Canaan, and people from all quarters go "up" to Jerusalem. It's also why the Lord comes "down" to us, which generally indicates a state of judgment.