In Genesis 12:10, this signifies much want in the Lord's internal man because of being instructed in celestial things before He was instructed in spiritual things. (Arcana Coelestia 1464)

In Genesis 21:11, this signifies the Lord's state from love when He thought of the merely human rational being separated from Himself. (Arcana Coelestia 2661)

In Revelation 16:2, this signifies interior evils and falsities destructive of good and truth in the church. (Apocalypse Revealed 678)