Genesis 3:1

¹ Now the serpent was more subtil than any beast of the field which the LORD God had made. And he said unto the woman, Yea, hath God said, Ye shall not eat of every tree of the garden?

Tread down or bruise

In Genesis 3:15, Isaiah 26:5-6, and 28:2-3, this signifies to subdue and overcome the lowest natural, which is the corporeal. (Arcana Coelestia 250)

In Leviticus 22:24, this signifies falsity or evil affecting something. (Apocalypse Explained 867[4])