Comfort
When the Bible talks about someone being comforted or consoled, it generally means that they are being offered ideas that will help bring them to a more peaceful spiritual state, whether it is a new state or the restoration of one that had been under attack. It's interesting; we tend to think of comforting someone as an emotional thing, offering our own feelings to help them feel better. But the Writings say that the spiritual meaning of 'comfort' is actually more intellectual, coming when a person gains new true ideas.
In Genesis 5:29, this signifies doctrine whereby what was perverted may be restored. (Arcana Coelestia 531)
In Genesis 27:42, this signifies intent to invert the current spiritual state.
To go up and to go down
Going up refers to going towards spiritual and celestial things, for these are inward things, and are also believed to be higher. Going down refers to going towards natural and earthly things, for these are outward things, and also appear lower.
(Odkazy: Arcana Coelestia 5406)