Apocalypse Explained # 303
303. Who is worthy to open the book and to loose the seals thereof? signifies, is there anyone there such as to know and to perceive the states of life of all? This is evident from the signification of "Who is worthy?" as being, is there anyone who has merit and righteousness, and who has omniscience, thus whether there is any such? That "worthy," in reference to the Lord, signifies merit and righteousness, which belong to Him alone, see above n. 293. And that omniscience is signified is clear from what follows, where it is said, "the Lamb took the book out of the right hand of Him that sat upon the throne, and opened it;" for "right hand" signifies omniscience and omnipotence (See above, n. 297); it is evident also from the signification of the "book," as being the states of life of all in general and in particular (of which see just above, n. 299); and also from the signification of "to open the book and to loose the seals thereof," as being to know and perceive; for when the "book" signifies the states of life of all, "to open and to loose the seals" signifies to know and perceive those states; for knowing and perceiving are predicated of the state of life, but opening and loosening seals relate to a book; thus the words in the internal sense conform to the things signified by the words in the sense of the letter, for they correspond; therefore, "to open" signifies to know, and "to loose the seals" signifies to perceive what is altogether hidden from others (as above, n. 300).
Isaiah 40:21-23
21
Haven't you known? Haven't you heard, yet? Haven't you been told from the beginning? Haven't you understood from the foundations of the earth?
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It is he who sits above the circle of the earth, and its inhabitants are like grasshoppers; who stretches out the heavens like a curtain, and spreads them out like a tent to dwell in;
23
who brings princes to nothing; who makes the judges of the earth like meaningless.