3449. 'And Isaac said to them, For what reason have you come to me, seeing that you hate me and have sent me away from you?' means, Why should they desire that which is Divine seeing that they refused to recognize it and loathed that which is contained in the internal sense of the Word? This becomes clear from what has been stated above at verses 15-16, 19-21.

577. Twelve means faith, or those things in their entirety that belong to love and faith deriving from it. Many details from the Word may confirm this - the twelve sons of Jacob and their names, the twelve tribes of Israel, and the Lord's twelve disciples. These matters however will in the Lord's Divine mercy be dealt with later on, in particular in Genesis 29, 30.