'Pouring out the vials upon the earth, which contained the plagues,' in Revelation 16:1, signifies influx of the reformed into the church, or into people who study and receive the doctrine of justification by faith alone.

(Odkazy: Apocalypse Explained 16; Apocalypse Revealed 676)

3247. 'And he sent them away from being with Isaac his son' means the distinguishing and separation of those who were spiritual from those who were celestial. This becomes clear from what has been stated immediately above - that the sons of Abraham by Keturah and by Hagar the Egyptian, who are called 'the concubines' sons' are those who are spiritual; that 'Isaac' in the relative sense means those who are celestial, 3245; and that they were separated.