'Pouring out the vials upon the earth, which contained the plagues,' in Revelation 16:1, signifies influx of the reformed into the church, or into people who study and receive the doctrine of justification by faith alone.

(Odkazy: Apocalypse Explained 16; Apocalypse Revealed 676)

220. 'His voice going to and fro' means that only a residue of perception was left, so small as to be solitary and inaudible, so to speak. This is also clear from the next verse in which it is said that Jehovah called out to the man. A similar usage occurs in Isaiah,

The voice of one crying in the wilderness; the voice said, Cry! Isaiah 40:3, 6.

'Wilderness' stands for a Church where no faith exists; 'the voice of one crying stands for the declaration of the Lord's coming, in general for every declaration of His coming, as is made to regenerate persons who have this dictate residing in them.