In Genesis 27:36, this signifies that the natural truth represented by Jacob had inverted the order of the natural good of the Lord's infancy represented by Esau. (Arcana Coelestia 3599)

In Hosea 12:3, this signifies that Jacob and his posterity from the beginning were merely natural, and thus opposed to the good of heaven and the church. (Apocalypse Explained 710[20])