Down" is used many different ways, and its spiritual meaning in the Bible is highly dependent on context. Phrases like "bowing down," "lying down" and "falling down" are defined primarily by "bowing," "lying" and "falling"; there is also a great difference between a person descending, the Lord sending fire from heaven and someone handling an object, to offer a few examples. In a very general sense, though, "down" indicates a lowering from more internal spiritual states to more external ones. That's why the journey is described as going "down" to Egypt from Canaan, and people from all quarters go "up" to Jerusalem. It's also why the Lord comes "down" to us, which generally indicates a state of judgment.

2275. That 'he said, Let not now my Lord be incensed, and I will speak' means deep concern over the state of the human race becomes clear not so much from the actual words as from the affection which these words have within them. The internal sense of the Word consists of two distinct elements - the spiritual and the celestial. The spiritual involves a discernment - abstractedly, apart from the letter - of subject matter or real things, the literal sense serving these as an object, in the same way as things seen with the eye may serve as objects of thought regarding more exalted matters. The celestial involves pure perception of the affection present within the real things which belong to the internal sense. That discernment of real things exists with spiritual angels, whereas this pure perception of that affection exists with celestial angels. The latter, that is, those who are percipients of the affection, perceive immediately, purely from the affection there, what the letter embodies within itself when this is being read by man. And from this they form celestial ideas for themselves, doing so with unending variety and in an indescribable fashion in accordance with the sequence and harmony of the celestial things of love comprising the affection. This shows what the Word of the Lord contains in its inner recesses. When these words are being read therefore, 'Let not now my Lord be incensed, and I will speak', celestial angels perceive immediately a certain deep concern, and indeed that deep concern that is a manifestation of love towards the human race. At the same time countless and indescribable aspects regarding the deep concern which the Lord felt when He thought about the state of the human race are instilled into them.