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Genesis 46:8

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8 And these [are] the names of the sons of Israel who are coming into Egypt: Jacob and his sons, Jacob's first-born, Reuben.

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To go up and to go down

  

Going up refers to going towards spiritual and celestial things, for these are inward things, and are also believed to be higher. Going down refers to going towards natural and earthly things, for these are outward things, and also appear lower.

(Referenties: Arcana Coelestia 5406)