'Pouring out the vials upon the earth, which contained the plagues,' in Revelation 16:1, signifies influx of the reformed into the church, or into people who study and receive the doctrine of justification by faith alone.

(Reference: Apocalypse Explained 16; Apocalypse Revealed 676)

In Revelation 1:4, this signifies the Lord's presence and providence; for the throne of God signifies the divine truth; thus heaven, which is the receptacle. (Apocalypse Explained 25)