Down
Down" is used many different ways, and its spiritual meaning in the Bible is highly dependent on context. Phrases like "bowing down," "lying down" and "falling down" are defined primarily by "bowing," "lying" and "falling"; there is also a great difference between a person descending, the Lord sending fire from heaven and someone handling an object, to offer a few examples. In a very general sense, though, "down" indicates a lowering from more internal spiritual states to more external ones. That's why the journey is described as going "down" to Egypt from Canaan, and people from all quarters go "up" to Jerusalem. It's also why the Lord comes "down" to us, which generally indicates a state of judgment.
Matthew 28:18-20
18
Jesus came to them and spoke to them, saying, "All authority has been given to me in heaven and on earth.
19
Go, and make disciples of all nations, baptizing them in the name of the Father and of the Son and of the Holy Spirit,
20
teaching them to observe all things that I commanded you. Behold, I am with you always, even to the end of the age." Amen.