'Pouring out the vials upon the earth, which contained the plagues,' in Revelation 16:1, signifies influx of the reformed into the church, or into people who study and receive the doctrine of justification by faith alone.

(Odkazy: Apocalypse Explained 16; Apocalypse Revealed 676)

This can, of course, be a wonderful thing: It is essential for our journey to heaven, and is the reason for the holiness of marriage. But when the men represent falsity it can also be horrendously twisted, as in the attempted homosexual rape in Sodom (Genesis 19) and the rape of the concubine in Gibeah (Judges 19). In a general sense, men represent things of the intellect -- facts, ideas, knowledge, everything from the deepest truths to the most pernicious falsities about life and the Lord. Women in general represents things of affection -- desire, passion, caring, everything from the most exalted love for the Lord to the darkest hatred. When a man “knows” a woman in the Bible, then, it represents a joining together of those intellectual and affectionate faculties. “Know" is also often used in connection with virginity. A women who has “not known a man” represents the affection for truth, unsullied by falsity.